in vitro study on Alzheimer disease: Objectives
Some reports have linked professional exposure to ELF-magnetic fields with an increased risk of Alzheimer. Recently a Swiss study also found a relationship between residential magnetic field exposure from power lines and mortality from neurodegenerative conditions such as Alzheimer disease. At present these studies are not conclusive yet and further research is needed.
Our objectives are to perform preliminary biological investigations to obtain data that may or may not support the alleged association between ELF-magnetic field exposure and such diseases. Therefore genetic damage in brain or nerve cells will be studied following in vitro and in vivo exposure to ELF-magnetic fields, but comparisons with other cell types need to be done as well. Investigation of other cell types will also be useful in the light of the controversy originating from the European 6 th framework REFLEX study that demonstrated that ELF-magnetic fields are able to induce genetic effects in some types of cells (but not in others) provided a given 'on/off' frequency is used.
We will use methods that reveal genetic damage that is expected to be associated with Alzheimer's disease.
This study should provide a confirmation or no-confirmation of earlier alarming papers. Inclusion of research on brain cells and the use of particular biomarkers will generate preliminary data and orientation for a more in depth investigation on the alleged relationship between ELF-MF exposure and neurodegenerative diseases.
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